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There have been some interesting studies suggesting that men who take Viagra might have a lower risk of developing Alzheimer’s disease. For example, one study found that men who used Viagra were 69% less likely to get Alzheimer’s over six years compared to those who didn’t. This led to headlines like “Men on Viagra may reduce their Alzheimer’s risk – study”. But let’s take a closer look at what this really means.

The Issue with Observational Studies
These studies are observational, meaning they can show a link but can’t prove that one thing causes the other. Just because two things happen together doesn’t mean one is causing the other.

Hidden Correlations
A big problem with these studies is hidden correlations. In this case, a reduced sex drive is an early symptom of Alzheimer’s disease. So, men who are starting to show early signs of Alzheimer’s might be less likely to use Viagra. This could explain why men who take Viagra seem to have a lower risk of Alzheimer’s—they might simply be less likely to have early symptoms of the disease in the first place.

Reinterpreting the Findings
Given this, the headline “Men on Viagra may reduce their Alzheimer’s risk – study” could be more accurately interpreted as “Men who don’t have symptoms of Alzheimer’s disease are less likely to use Viagra.” This shows why it’s important not to jump to conclusions based on these kinds of studies.

Other Confounding Factors
It’s also important to consider that sexually active individuals often lead different lifestyles. They may be more likely to have a loving partner, be physically healthy, play sports, and have a strong community. Each of these factors can contribute to overall well-being and cognitive health, potentially influencing the study’s findings. These hidden confounding factors further complicate the interpretation of the results.

In summary, while the findings are interesting and worth further research, it’s important to remember that correlation does not equal causation. More rigorous studies are needed to determine if Viagra truly has a protective effect against Alzheimer’s disease.

Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10977448/

By Jack Auty

Jack Auty has a Ph.D. in pharmacology from the University of Otago and is now a Post-Doctoral researcher at the University of Manchester investigating the pathology of Alzheimer's Disease.